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KMID : 0438219780150030229
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Korea University Medical Journal
1978 Volume.15 No. 3 p.229 ~ p.237
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Intravitreal Amikacin and Gentamicin Sulfate in the Treatment of Induced Staphylococcal Endophthalmitis
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Abstract
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Endophthalmitis is one of the most serious complications of intraocular surgery and penetrating injuries.
Direct intravitreal injection has been utilized by a number of ophthalmologists in the treatment of endophthalmitis because of the poor ocular penetration of antibiotics administered by alternate routes.
After experimental endophthalmitis was produced by inoculating staphylococcus aureus (25-100 organisms/0.05ml) into the vitreous cavity through the pars plans at 12 o´clock position in rabbits, the investigation was performed to evaluate the therapeutic results of the following 6 divided experimental groups:
A) Control. group (20 eyes). .
B) Treatment group_with 0.3mg intravitreal amikacin (20 eyes).
Q. Treatment group with 0.1mg intravitreal gentamicin (20 eyes).
D), Vitreous aspiration group (20 eyes). ,
E) Combined group of B) and D). (20 eyes).
F) Combined group of C) and D) (20 eyes).
Especially., the author closely observed that elimination of microorganism was compared using intravitreal administration of gentamicin sulfate alone or amikacin sulfate alone, combination of gentamicin or`amikacin. sulfate and vitreous aspiration.
The. vitreous: was cultured in all eyes one week after treament, and the results were as criteria for.:suecgss~or failure of, treatment.
The.r_esjg%yeregy #ollows _
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.".1 ;O# t Of ges~_T", ving no _treatment (A group) and 20 eyes receiving vitreous aspiration rall:eVre; posigve~ at one wpek tafte´ , treatment.:
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2) Of the 20 eyes treated with´ intravitreal amikacin (B group) 24 hours after inoculation of S. aureus, 9 eyes (45%) were culture negative after one Nveek, while E group were culture negative in 85% of cases.
3) Of the 20 eyes treated with intravitreal gentamicin (C group) 24 hours after inoculation of S. aureus, 8 eyes (400,6) were culture negative after one week; while eyes treated with vitreous aspiration and intravitreal gentamicin-treated group (F group) were cultur,: negative in 750"0 of cases.
4) From those results, it was concluded that effect of treatment with vitreous aspiration alone was suspicous, while vitreous aspiration with intravitreal antibiotics was reasonable results in the bacterial endophthalmitis.
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